First look: Green Bay Packers at San Francisco 49ers odds and lines

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Sportsbook Wire

The Green Bay Packers (1-1) visit the San Francisco 49ers (2-0) for a Sunday night affair at Levi's Stadium in Santa Clara, Calif. Kickoff in the Week 3 contest is slated for 8:20 p.m. ET. Below, we look at the Packers vs. 49ers odds and lines; check back for our NFL picks and predictions.

Green Bay is lined up for a second straight night game after a 35-17 win over the Detroit Lions in the Week 2 Monday night'er. The Packers outscored the Lions 21-0 in the second half and were plus-2 in turnovers. QB Aaron Rodgers completed 22 of 27 passes for 255 yards and 4 touchdowns.

The 49ers were held off the scoreboard until the 12-second mark of the second quarter in their Sunday 17-11 road win at the Philadelphia Eagles. A QB Jimmy Garoppolo TD pass with 10:52 to go capped off a 97-yard scoring drive which vaulted the 49ers to a lead they would not relinquish.

Packers at 49ers odds, spread and line

Odds provided by Tipico Sportsbook; access USA TODAY Sports' betting odds for a full list. Lines last updated Tuesday at 7:47 a.m. ET.

  • Money line: Packers +160 (bet $100 to win $160) | 49ers -200 (bet $200 to win $100)
  • Against the spread (ATS): Packers +3.5, -115 (bet $107 to win $100) | 49ers -3.5, -115 (bet $115 to win $100)
  • Total (O/U): 47.5, Over -110 (bet $110 to win $100) | Under -110 (bet $110 to win $100)

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2021 betting stats:

  • ML : Packers 1-1 | 49ers 2-0
  • ATS : Packers 1-1 | 49ers 1-1
  • O/U : Packers 1-1 | 49ers 1-1

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Packers at San Francisco 49ers head-to-head

The Over is 9-3 in the last 12 meetings between Green Bay and San Francisco. The last of those meetings was Nov. 5, 2020, a 34-17 Packer win in Santa Clara. Including playoff meetings, Green Bay is 3-6 (2-7-1 ATS) against the 49ers over the last 10 years.

The Packers lead the all-time series 37-32-1.

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